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Standards Development
This document specifies a method for the determination of the amount of 2,3-Butanedione as their 2,4- Dinitrophenylhydrazones in E-liquids of vapour products by HPLC-UV/ DAD.
2,3-Butanedione (diacetyl) is a typical flavor compound. It potentially causes diseases when inhaled, including bronchiolitis obliterans syndrome, obliterative bronchiolitis, or impaired lung function. 2,3- Butanedione is on the list of substances which should be controlled in e-liquids in many countries, such as China (SAC, GB 41700, with a maximum allowable concentration of 22.0 mg/kg in e-liquid) and France (AFNOR, XP D 90-300-2, with a maximum allowable concentration of 22 mg/L in e-liquid). Because of the potential undesirable effects of 2,3-butanedione on health and safety of vapour products, the development of an adequate and validated analytical method for quantification of 2,3- butanedione in e-liquids in vapour products is highly necessary for quality control of vapour products. HPLC have been proved to be a reliable, accurate, and reproducible method for determination of 2,3- butanedione in e-liquids by a derivatization reaction with acidified solution of 2,4-dinitrophenylhydrazine (DNPH). The proposed method can be applied by academic bodies, industries and regulators, not only for quality control of vapour products, but also for supervision and regulation purposes. (Please use this field or attach an annex)
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